3，3，3-三甲氧基丙腈的合成与表征

以丙二腈为起始原料通过两步反应合成了3，3，3-三甲氧基丙腈，气相色谱分析产物纯度达到98．08％。采用气质联用、红外光谱、核磁共振氢谱对产物进行了表征。确定了第一步合成甲基氰基乙酰亚氨基盐酸盐的最佳反应条件为：溶剂含水量〈100×10-6^、通气时间3h、72g丙二腈、45mL甲醇、1440mL乙醚、常温搅拌时间7h；第二步合成3，3，3-三甲氧基丙腈的最佳反应条件为：甲基氰基乙酰亚氨基盐酸盐与甲醇的物料比为1g：7．35mL、搅拌时间24h、在反应i0h后移出副产物氯化铵、无水硫酸钠作为干燥剂。

Synthesis and Characterization of 3,3,3-Trimethoxypropanenitrile

3,3,3-Trimethoxypropanenitrile was synthesized after two-step reactions by using malononitrile as raw material. Through the analysis of gas chromatography, the product purity reached 98.08%. GC-MS, IR and 1HNMR were applied to the product characterization. The optimum reaction conditions of the first step to synthesize methyl cyanoacetimidate hydrochloride were determined as follows：water content of solvent less than 100 X 10-6, ventilation time of 3 h, malononitrile amount of 72 g, methanol amount of 45 mL, ether amount of 1440 mL, stirring for 7 h at room temperature. The optimum reaction conditions of the second step to synthesize 3,3,3-trimethoxypropanenitrile were as follows：the ratio of methyl cyanoacetimidate hydrochloride to methanol of 1 g ： 7.35 mL, stirring time of 24 h,removing ammonia chloride after reacted for 10 h,using anhydrous sodi- um choloride as drying agent.