| 碳酸钾催化绿色合成2-氨基-3-氰基-1,4,5,6-四氢吡喃并[3,2-c]喹啉-5-酮衍生物 |
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| 引用本文： | 姚孟建.碳酸钾催化绿色合成2-氨基-3-氰基-1,4,5,6-四氢吡喃并[3,2-c]喹啉-5-酮衍生物[J].湖北化工,2012(4):51-53. |
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| 作者姓名： | 姚孟建 |
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| 作者单位： | 西南大学化学化工学院生物有机化学实验室,重庆400715 |
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| 摘 要： | 以4-羟基喹啉-2-酮、丙二腈、芳醛为起始原料,以碳酸钾为催化剂,在乙醇中一锅合成了2-氨基-3-氰基-1,4,5,6-四氢吡喃并3,2-c]喹啉-5-酮衍生物。该方法具有反应条件温和、操作简单、产物易纯化、产率高等优点,是一种无毒、高效的绿色合成方法。
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| 关 键 词： | 4-羟基喹啉-2-酮 丙二腈 芳醛 碳酸钾 |
Green Synthesis of 2-Amino-3-cyano-1,4,5,6-tetrahydropyranoquinolin-5-one Derivatives Catalyzed by Potassium Carbonate |
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| YAO Meng-jian.Green Synthesis of 2-Amino-3-cyano-1,4,5,6-tetrahydropyranoquinolin-5-one Derivatives Catalyzed by Potassium Carbonate[J].Hubei Chemical Industry,2012(4):51-53. |
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| Authors: | YAO Meng-jian |
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| Affiliation: | YAO Meng-jian(Laboratory of Bioorganic Chemistry,School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China) |
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| Abstract: | Using potassium carbonate as catalyst,2-amino-3-cyano-1,4,5,6-tetrahydropyranoquinolin-5-one derivatives are synthesized in ethanol by one-pot method with 4-hydroxyquinlin-2-（1H）-one,malononitrile and aryl aldehyde as raw materials.This synthetic method is green and effective with mild reaction conditions,simple operation,easy purification and high yield. |
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| Keywords: | 4-hydroxyquinolin-2（1H）-one malononitrile aryl aldehyde potassium carbonate |
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