Chemically functionalized water-soluble single-walled carbon nanotubes modulate morpho-functional characteristics of astrocytes |
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Authors: | Manoj K Gottipati Irina Kalinina Elena Bekyarova Robert C Haddon Vladimir Parpura |
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Affiliation: | Department of Neurobiology, University of Alabama , Birmingham, Alabama 35294, United States. |
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Abstract: | We report the use of chemically functionalized water-soluble single-walled carbon nanotubes (ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When added to the culturing medium, ws-SWCNTs were able to make astrocytes larger and stellate/mature, changes associated with the increase in glial fibrillary acidic protein immunoreactivity. Thus, ws-SWCNTs could have more beneficial effects at the injury site than previously thought; by affecting astrocytes, they could provide for a more comprehensive re-establishment of the brain computational power. |
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