| 4H-[1]苯并吡喃[3,4-d]异噁唑-4-酮的合成(英文) |
| |
| 引用本文： | 邓兴国,邢媛媛,王有名,周正洪. 4H-[1]苯并吡喃[3,4-d]异噁唑-4-酮的合成(英文)[J]. 精细化工中间体, 2012, 42(4): 32-35 |
| |
| 作者姓名： | 邓兴国 邢媛媛 王有名 周正洪 |
| |
| 作者单位： | 1. 湖南食品药品职业学院,湖南 长沙,410014
2. 南开大学 元素有机化学研究所,天津,300071 |
| |
| 摘 要： | 芳酰乙酸乙酯在乙氧基镁的作用下与取代的苯甲酰氯反应生成2-取代苯并吡喃酮。2-取代苯并吡喃酮和盐酸羟胺经Beckmann重排反应合成了4H-[1]苯并吡喃[3,4-d]异噁唑-4-酮。X衍射谱图表明,反应过程中表现区域选择性。对该反应的反应机理进行了初探。
|
| 关 键 词： | 4H-[1]苯并吡喃[3,4-d]异噁唑-4-酮 区域选择性 Beckmann重排 机理 |
Synthesis of 4H-[1]Benzopyrano[3,4-d]isoxazol-4-ones |
| |
| DENG Xing-guo , XING Yuan-yuan , WANG YOU-ming , ZHOU Zheng-hong. Synthesis of 4H-[1]Benzopyrano[3,4-d]isoxazol-4-ones[J]. Fine Chemical Intermediates, 2012, 42(4): 32-35 |
| |
| Authors: | DENG Xing-guo XING Yuan-yuan WANG YOU-ming ZHOU Zheng-hong |
| |
| Affiliation: | 1.Hunan Food and Drug Vocational College,changsha 410014,China;2.State Key Laboratory of ElementoOrganic Chemistry,Nankai University,Tianjin 300071,China) |
| |
| Abstract: | Ethyl benzoylacetate reacted with acetylsalicyloyl chloride in the presence of magnesium ethylate and ethyl 2-aryl-4-oxo-4H-[1]benzopyran-3-carbonate were gained,which reacted with hydroxylamine via Beckmann rearrangement and 4H-[1]benzopyrano[3,4-d]isoxazol-4-ones were gained.X-Ray analysis result of compound 2b confirmed the regioselectivity of the reaction.The mechanism of the formation of 4H-[1] benzopyrano[3,4-d]isoxazol-4-ones is also investigated. |
| |
| Keywords: | 4H-[1]benzopyrano[3,4-d]isoxazol-4-one regionselectivity Beckmann rearrangement mechanism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
