顶空气相色谱法测定盐酸氮卓斯汀中残留溶剂

建立毛细管气相色谱法测定盐酸氮卓斯汀中残留溶剂。采用DB-624毛细管色谱柱,FID检测器,二甲基甲酰胺为溶剂,程序升温,外标法同时检测盐酸氮卓斯汀中乙醇、丙酮、二氯甲烷、正己烷4种有机溶剂残留量。各待测组分完全分离,线性关系良好,检测限分别为3.51μg/mL、 0.35μg/mL、 2.12μg/mL、 0.11μg/mL,精密度RSD<5%,平均回收率99.1%-102.4%。本法操作简单,结果准确可靠,可用于盐酸氮卓斯汀中残留溶剂的检测。

Determination of residual solvents in azelastine hydrochloride by head space gas chromatography

To establish a method for determining the four kinds of residual solvents in azelastine hydrochloride by headspace gas chromatography.The determination was carried out on a DB-624 capillary column(30mm×0.53mm, 3μm) with sequential increase of temperature programming.N,N-dimethyformamide as solvent media,with the FID detector It appears a good linearity in the experimental concentration(r?0.9991).The detector limit of etha- nol,acetone,chloromethane and n-hexane separately were 3.51,0.35,2.12,0.11 μg/mL.The RSD of precision were all less than5.0%.The average recoveries were 99.1%～102.4%.The method is simple,sensitive and accurate ? It could be used for detection of four residual solvents in azelastine hydrochloride.