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Antioxidant,anticholinesterase and antimicrobial constituents from the essential oil and ethanol extract of Salvia potentillifolia
Authors:?brahim Kivrak  Mehmet Emin Duru  Mehmet Öztürk  Nazime Mercan  Mansur Harmandar  Gülaçt? Topçu
Affiliation:1. Mu?la University, Faculty of Arts and Sciences, Department of Chemistry, 48121 Mu?la, Turkey;2. Pamukkale University, Faculty of Arts and Sciences, Department of Biology, 20017 Denizli, Turkey;3. Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey
Abstract:The essential oil of Salvia potentillifolia was analysed by GC and GC–MS. Totally, 123 components were detected in both hydrodistilled and steam-distilled oils, α- and β-pinenes being major compounds. The antioxidant activities were determined by using complementary tests, namely, DPPH radical-scavenging, β-carotene-linoleic acid and reducing power assays. The ethanol extract also showed better activity (IC50 = 69.4 ± 0.99 μg/ml) than that of BHT in the DPPH system, and showed great lipid peroxidation inhibition in the β-carotene-linoleic acid system (IC50 = 30.4 ± 0.50 μg/ml). The essential oil showed meaningful butyrylcholinesterase activity (65.7 ± 0.21%), and α-pinene showed high acetylcholinesterase inhibitory activity (IC50 = 86.2 ± 0.96 μM) while β-pinene was inactive. Antimicrobial activity was also investigated on several microorganisms, and the essential oil showed high activity against Bacillus subtilis and B. cereus. It also exhibited remarkable anticandidal activity against Candida albicans and C. tropicalis with MIC values of 18.5 and 15.5 μg/ml, respectively, while α- and β-pinenes showed moderate activity.
Keywords:Lamiaceae  Salvia potentillifolia  Antioxidant activity  Antimicrobial activity  Anticholinesterase activity  Essential oil  GC&ndash  MS
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