Synthesis of nanoporous calcium phosphate spheres using poly(acrylic acid) as a structuring unit |
| |
| Authors: | Peng Wang Se-Won Yook Shin-Hee Jun Yuan-Long Li Miyoung Kim Hyoun-Ee Kim Young-Hag Koh |
| |
| Affiliation: | 1. Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India;2. Biomedical Engineering Department, University of Memphis, Joint University of Memphis–University of Tennessee Graduate Biomedical Engineering Program, Memphis, TN, USA;1. Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere, 100-00133 Rome, Italy;2. Department of Biomedical and Pharmaceutical Sciences, Center for Targeted Drug Delivery, Chapman University, Irvine, CA 92618-1908, USA;3. AA Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninsky prospect 49, 119991 Moscow, Russia |
| |
| Abstract: | Calcium phosphate (CaP) spheres with nanopores were synthesized using poly(acrylic acid) (PAA) as the structuring unit. In this method, colloidal droplets of the PAA/Ca2+ complex were prepared by adding a Ca(NO3)2 solution to a PAA aqueous solution and then mixed with an (NH4)2HPO4 solution, which allowed the nucleation and growth of CaP nanocrystals in the PAA matrix. Thereafter, the as-synthesized PAA/CaP spheres were heat-treated at 550 °C for 3 h to remove the PAA phase, followed by treatment in ammonium nitrate solution to remove the CaO phase formed as an impurity. The prepared CaP spheres showed a narrow size distribution with an average diameter of 146 ± 43 nm and nanopores formed via the removal of the CaO phase. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
