DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties |
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| Authors: | T Takahashi H Tanaka A Matsuda T Doi H Yamada T Matsumoto D Sasaki Y Sugiura |
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| Affiliation: | Department of Chemical Engineering, Tokyo Institute of Technology, Japan. |
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| Abstract: | The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage. |
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