Optimal designs for dual response systems for the normal and binomial case |
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Authors: | Sarah E Burke Douglas C Montgomery Christine M Anderson-Cook Rachel T Silvestrini Connie M Borror |
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Affiliation: | 1. The Perduco Group – A Linquest Company, Dayton, Ohio, USA;2. Arizona State University, Tempe, Arizona, USA;3. Los Alamos National Laboratory, Los Alamos, New Mexico, USA;4. Eli Lilly, Indianapolis, Indiana, USA;5. Arizona State University, Glendale, Arizona, USA |
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Abstract: | Most research in design of experiments focuses on appropriate designs for a system with just one type of response, rather than multiple responses. In a decision-making process, relying on only one objective can lead to oversimplified, suboptimal choices that ignore important considerations. Consequently, the problem of constructing a design for an experiment when multiple types of responses are of interest often does not have a single definitive answer, particularly when the response variables have different distributions. Each of these response distributions imposes different requirements on the experimental design. Computer-generated optimal designs are popular design choices for less standard scenarios where classical designs are not ideal. This work presents a new approach to experimental designs for dual-response systems. The normal and binomial distributions are considered as potential responses. Using the D-criterion for the linear model and the Bayesian D-criterion for the logistic regression model, a weighted criterion is implemented in a coordinate-exchange algorithm. Designs are evaluated and compared across different weights. The sensitivity of the designs to the priors supplied for the Bayesian D-criterion is also explored. |
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Keywords: | Bayesian D-optimal design case studies desirability function dual-response nonlinear model experimental design optimal design reliability |
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