Effects of polydatin on the proliferation,migration, and invasion of ovarian cancer

To investigate the effects of polydatin on the proliferation, migration, and invasion of ovarian cancer, thechange of proliferative ability, migration ability, and invasive ability of human ovarian cancer cell OVCAR-3, A2780,and HO-8910 was detected by using polydatin and up-regulating PI3K. The anticancer activity and mechanism ofpolydatin in ovarian cancer were analyzed. Polydatin could effectively inhibit the proliferation, migration, and invasionof OVCAR-3, A2780, and HO-8910, and inhibit the expression of PI3K protein. After the expression level of PI3Kprotein was up-regulated, the inhibitory effect of polydatin on the proliferative ability, migration ability, and invasiveability of OVCAR-3, A2780, and HO-8910 significantly decreased, suggesting that PI3K was the target of polydatin.Therefore, we concluded that polydatin could inhibit the proliferation, migration, and invasion of ovarian cancer cellsby inhibiting the expression of PI3K protein, which provides an experimental basis for polydatin in the treatment ofovarian cancer.