Changes in lipids in liver and serum of rats fed a histidine-excess diet or cholesterol-supplemented diets |
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Authors: | Ohmura Eri Aoyama Yoritaka Yoshida Akira |
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Affiliation: | (1) Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, School of Agriculture, Nagoya University, Furo-cho, Chikusa, 464 Nagoya, Japan |
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Abstract: | The influence of dietary excess (5%) L-histidine on serum and liver lipids was examined in rats. Feeding a histidine-excess
diet for 3, 6, 14 or 30 days caused growth retardation, hepatomegaly and decreased liver lipids throughout the period of the
experiment. Hypercholesterolemia was observed after feeding a histidine-excess diet for 6 days; then serum cholesterol continuously
increased for 30 days. Serum triglyceride on day 30 in rats fed the histidine-excess diet showed a significant decrease compared
to rats fed the basal diet. Serum phospholipids of rats fed the histidine-excess diet for 7 or 14 days showed a significant
increase compared to rats fed the basal diet. When rats were fed a basal, histidine-excess or cholesterol-supplemented diet
(0.5% and 1.0% cholesterol) for 6 days, the distribution of serum high density (HDL), low density (LDL) and very low density
lipoprotein cholesterol in rats fed the histidine-excess diet was similar to that of rats fed the basal diet, whereas LDL-cholesterol
increased and HDL-cholesterol decreased in rats fed the cholesterol-supplemented diet. |
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Keywords: | |
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