桑叶有效成份降糖作用研究

目的：研究桑叶中有效成分的降糖作用。方法：通过动物实验研究桑叶多糖、黄酮及生物碱对链脲佐菌素致糖尿病模型小鼠的血糖、血脂及糖耐量的影响。结果：桑叶多糖、黄酮、生物碱成分均可显著降低糖尿病模型小鼠的血糖值，增加其糖耐量，对抗糖尿病所伴随的血脂异常，其血糖下降率分别为14.42%、27.33%及37.55%。结论：桑叶多糖、黄酮、生物碱对糖尿病有一定的预防及治疗作用。其中生物碱的降糖作用最为显著，效果优于阳性对照品。

Hypoglycemic Effect of Bioactive Components in Mulberry Leaves

Objective: To explore the hypoglycemic effect of polysaccharides, flavonoids and alkaloids from mulberry leaves. Methods: A mouse model of diabetes was established to explore the effects of mulberry leaf polysaccharides, flavonoids and alkaloids on blood glucose, blood lipid and glucose tolerance. Results: The polysaccharides, flavonoids and alkaloids could obviously decrease blood glucose, improve glucose tolerance, and resist abnormal blood lipid in diabetic mice. The reduction rates of blood glucose in mice administered with mulberry leaf polysaccharides, flavonoids and alkaloids were 14.42%, 27.33% and 37.55%, respectively. Conclusion: Mulberry leaf polysaccharides, flavonoids and alkaloids can prevent and treat diabetes. Mulberry leaf alkaloids have obvious hypoglycemic effect and exhibit better hypoglycemic function than the positive reference substance metformin.