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Mechanisms of aerosol deposition in a nasal model |
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| Authors: | H. Itoh G.C. Smaldone D.L. Swift H.N. Wagner Jr. |
| Affiliation: | a Department of Nuclear Medicine, Kyoto University Hospital, Shyogoin Kawara cho, Sakyo ku, Kyoto 606, Japan b Pulmonary Disease Division, Department of Medicine, State University of New York, Stony Brook, NY 11794, U.S.A. c Division of Environmental Health Engineering, Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, U.S.A. d Division of Radiation Health Sciences, Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, U.S.A. |
| Abstract: | Total and regional aerosol deposition were investigated in a model of a normal human nasal airway. Contributions of fluid turbulence and particle inertia were evaluated using monodisperse aerosols. At fixed turbulent flow conditions, deposition percentage increased with particle size greater than 1 μm, suggesting that turbulent inertial deposition is a primary mechanism. With same size aerosol, deposition increased with increasing fluid turbulence but its contribution was less with larger size aerosol. Turbulent diffusion was the dominant transport mechanism for particles less than 1 μm, where deposition decreased with particle size. Two major deposition sites were visualized with radio-aerosol in the anterior region of the nasal airway. One is close to the ostium internum where turbulent eddies are well developed, and the other is the anterior region of the middle turbinate where direction of airflow changes from upward to horizontal. |
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