| 卵磷脂/蒙脱土纳米中间体的制备及血液相容性研究 |
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| 引用本文： | 方苏,周宁琳,徐东,高孝俊,章峻,莫宏,沈健.卵磷脂/蒙脱土纳米中间体的制备及血液相容性研究[J].功能材料,2009,40(7). |
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| 作者姓名： | 方苏 周宁琳 徐东 高孝俊 章峻 莫宏 沈健 |
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| 作者单位： | 1. 南京师范大学江苏省生物医药功能材料工程研究中心,江苏南京210097;南京师范大学江苏省生物功能材料重点实验室,江苏南京210097
2. 南京师范大学江苏省生物医药功能材料工程研究中心,江苏南京210097;南京师范大学江苏省生物功能材料重点实验室,江苏南京210097;南京大学江苏省表面与界面工程技术研究中心,江苏南京210093 |
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| 基金项目： | 国家自然科学基金资助项目(20874047);;国家高技术研究发展计划(863计划)专项资助项目(2006AA032Z445);;教育部博士点基金资助项目(20050319010);;江苏省教育厅基金资助项目(JHB05-21) |
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| 摘 要： | 通过插层技术合成了卵磷脂/蒙脱土(PC/MMT)纳米中间体,利用XRD、FT-IR对合成的卵磷脂/蒙脱土纳米中间体进行了表征,结果表明卵磷脂已进入了蒙脱土层间,其层间距高达6.13nm;通过溶血试验和血浆复钙试验评价了PC/MMT纳米中间体的血液相容性,试验结果表明PC/MMT纳米中间体的溶血率<5%,符合生物医学材料的标准,复钙时间较长,有良好的血液相容性;预示了其在生物医药领域的潜在应用性.
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| 关 键 词： | 蒙脱土 卵磷脂 血液相容性 |
Preparation and hemocompatibility of phosphatidylcholine/montmorillonite nanocomposites |
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| FANG Su
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ZHOU Ning-lin
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XU Dong
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GAO Xiao-jun
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ZHANG Jun
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MO Hong
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SHEN Jian.Preparation and hemocompatibility of phosphatidylcholine/montmorillonite nanocomposites[J].Journal of Functional Materials,2009,40(7). |
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| Authors: | FANG Su ZHOU Ning-lin XU Dong GAO Xiao-jun ZHANG Jun MO Hong SHEN Jian |
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| Affiliation: | 1.Jiangsu Engineering Research Center for Biomedical Function Materials;Nanjing Normal University;Nanjing 210097;China;2.Jiangsu Key Laboratory of Biofunctional Materials;College of Chemistry and Environmental Science;3.Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering;Nanjing University;Nanjing 210093;China |
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| Abstract: | In this research,a novel nanocomposite-phosphatidylcholine/montmorillonite(PC/MMT) was prepared through solution intercalated reaction.The properties of this nanocomposites were characterized by X-ray diffraction(XRD),Fourier transformed infrared(FT-IR).The results showed that PC had intercalated into MMT.The basal spacing of montmorillonite is high to 6.13nm.Blood compatibility of PC/MMT nanocomposites were evaluated by haemolysis test and plasma recalcification time test(PRT).The haemolysis rate of PC/MMT... |
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| Keywords: | montmorillonite phosphatidylcholine blood compatibility |
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