Two New Fatty Acid Derivatives from the Stem Bark of <Emphasis Type="Italic">Alchornea laxiflora</Emphasis> (Euphorbiaceae) |
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| Authors: | Louis Pergaud Sandjo Hervé M Poumale Poumale Xavier Noudou Siwe Hippolyte Nga Ntede Yoshihito Shiono Bonaventure Tchaleu Ngadjui Rui M W Krause Derek Tantoh Ndinteh Joseph Tanyi Mbafor |
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| Affiliation: | 1.Department of Organic Chemistry,University of Yaoundé I,Yaoundé,Cameroon;2.Department of Bioresource Engineering, Faculty of Agriculture,Yamagata University,Tsuruoka,Japan;3.National Advanced School of Engineering,University of Yaoundé I,Yaoundé,Cameroon;4.Department of Pharmacy and Traditional Pharmacopeia, Faculty of Medicine and Biomedical Sciences,University of Yaoundé I,Yaoundé,Cameroon;5.Department of Chemical Technology,University of Johannesburg,Johannesburg,South Africa |
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| Abstract: | Euphorbiaceae is a family of plants used in traditional remedies in central Africa to treat selected diseases. Some of the
phytochemical components in the stem bark of Alchornea laxiflora that have biochemical activity were identified. A number of novel compounds were isolated, including a new fatty acid ester,
(1) a new ceramide, (2) some triterpenoids, (3–5), ellagic acid (6) and its derivatives (7, 8) were isolated. The structures of these compounds were determined on the basis of spectroscopic methods as well as HR-ESI-TOF-MS
analysis, chemical transformation and by comparison of their physical and spectral data with those reported in the literature.
The cytotoxicity of some isolated compounds was investigated against human promyelocytic leukaemia (HL60) cell line by using
the MTT method. Compounds 1, 4 and 5 showed a cytotoxic activity with IC50 at 58.7, 6.6 and 6.8 μM, respectively. |
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