Ibuprofen loaded porous calcium phosphate nanospheres for skeletal drug delivery system |
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Authors: | Fengwei Shao Lin Liu Kejie Fan Yurong Cai Juming Yao |
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Affiliation: | (1) The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Xiasha Higher Education Park, Hangzhou, 310018, China; |
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Abstract: | Porous calcium phosphate nanospheres were successfully fabricated by a simple sonochemical method, and used as a drug carrier
of ibuprofen. Morphology, structure, ibuprofen storage capacity, and release rate of the calcium phosphate nanospheres were
characterized using FE-SEM, TEM, Nitrogen adsorption, XRD, FTIR, and UV–vis adsorption spectroscopies. Results showed the
obtained calcium phosphate nanospheres held a porous structure with an average diameter of 48.9 ± 17.42 nm. Moreover, the
porous nanospheres possessed an adjustable load amount and release rate for ibuprofen by changing drug concentrations during
the drug loading process. In addition, the effects of size and dispersancy of porous spheres on drug release rate were discussed,
which was found that larger or agglomerate porous spheres could delay drug release process. This study indicated that porous
calcium phosphate nanospheres were a perfect drug carrier for ibuprofen, which has potential application for the therapy of
skeletal disease. |
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Keywords: | |
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