An antibacterial composite system based on multi-responsive microgels hosting monodisperse gold nanoparticles |
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Authors: | Damla Ulker Cansel Tuncer Serife B Sezgin Yagmur Toptas Ahmet Cabuk Vural Bütün |
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Affiliation: | 1.Department of Polymer Science and Technology,Eskisehir Osmangazi University,Eskisehir,Turkey;2.Department of Chemistry,Eskisehir Osmangazi University,Eskisehir,Turkey;3.Department of Biology, Graduate School of Natural and Applied Sciences,Eskisehir Osmangazi University,Eskisehir,Turkey;4.Department of Biology,Eskisehir Osmangazi University,Eskisehir,Turkey |
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Abstract: | A multi-responsive microgel having response to pH, temperature, and salt concentration was successfully prepared using a water-soluble monomer. Microgels were readily prepared from 2-(N-morpholino)ethyl methacrylate (MEMA) via emulsion polymerization using glycidyl methacrylate as a comonomer cross-linker. The morpholino groups of MEMA residues of microgels were able to give complexation with metal containing anions such as AuCl4 ? in acidic conditions. The reduction of aurate ions with sodium borohydride led to immobilized-gold nanoparticles (AuNP) in the microgel system. Average particle diameters of AuNPs were determined to be 10 ± 2 nm. The resulting AuNP-microgel system was examined as a nanoreactor for catalyst system and determined to be very effective in the reduction of 4-nitrophenol model reaction in aqueous media. AuNPs-microgel composite system had antibacterial properties against several Gram-positive and Gram-negative bacteria similar to amoxicillin. This P(MEMA-co-GMA) microgel is also very useful for different applications such as a host for metal nanoparticle production, a drug carrier or drug delivery system. |
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