Distribution of free D-amino acids in tissues and body fluids of vertebrates |
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| Authors: | K Imai T Fukushima T Santa H Homma Y Huang K Sakai M Kato |
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| Affiliation: | Faculty of Pharmaceutical Sciences, University of Tokyo, Japan. |
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| Abstract: | Reports on the distribution, metabolism and origins of free D-amino acids in vertebrate tissues and body fluids are reviewed. The transient emergence of D-aspartic acid during the development of brain and peripheral organs or early stages of life is reported. D-Serine in brain is postulated to be a potentiator for the N-methyl-D-aspartate (NMDA) receptor. Some D-amino acid concentrations in human serum, such as D-Ser and D-Ala, are suggested to correlate with damage to renal function. |
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