| Synthesis of 2-Substituted Benzimidazol-N-biphenyl Acid and Crystal Structure of 4'-[(2-n-Propyl-1H-benzimidazol-1-yl)methyl] Biphenyl-2-carboxylate Acid |
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| 作者姓名： | 余伟发 周智明 赵信岐 余从煊 |
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| 作者单位： | School of Chemical Engineering and Environment Beijing Institute ofTechnology，Beijing 100081，China，School of Chemical Engineering and Environment Beijing Institute ofTechnology，Beijing 100081，China，School of Material Science and Engineering Beijing Institute of Technology，Beijing 100081，China，School of Chemical Engineering and Environment Beijing Institute ofTechnology，Beijing 100081，China |
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| 摘 要： | Nine analogues of telmisartan, 2-substituted benzimidazol-N-biphenyl acid, were designed and synthesized, from substituted benzimidazoles reacted with methyl 4'-(bromomethyl)- -biphenyl-2-carboxylate, then hydrolysis with KOH in MeOH and H2O. Their structures were confirmed by IR, 'H NMR, MS spectroscopy and elemental analysis. The crystal structure of 4'-(2-n-propyl-1H-benzimidazol-lyl) methyl] biphenyl-2-carboxylic acid was determined by single crystal X-ray diffraction.
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Synthesis of 2-Substituted Benzimidazol-N-biphenyl Acid and Crystal Structure of 4'-[(2-n-Propyl-1H-benzimidazol-1-yl)methyl] Biphenyl-2-carboxylate Acid |
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| YU Wei-fa ZHOU Zhi-ming ZHAO Xin-qiYU Cong-xuan.Synthesis of 2-Substituted Benzimidazol-N-biphenyl Acid and Crystal Structure of 4''''-[(2-n-Propyl-1H-benzimidazol-1-yl)methyl] Biphenyl-2-carboxylate Acid[J].Journal of Beijing Institute of Technology,2004(Z1). |
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| Authors: | YU Wei-fa ZHOU Zhi-ming ZHAO Xin-qiYU Cong-xuan |
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| Abstract: | Nine analogues of telmisartan, 2-substituted benzimidazol-N-biphenyl acid, were designed and synthesized, from substituted benzimidazoles reacted with methyl 4'-(bromomethyl)- -biphenyl-2-carboxylate, then hydrolysis with KOH in MeOH and H2O. Their structures were confirmed by IR, 'H NMR, MS spectroscopy and elemental analysis. The crystal structure of 4'-(2-n-propyl-1H-benzimidazol-lyl) methyl] biphenyl-2-carboxylic acid was determined by single crystal X-ray diffraction. |
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| Keywords: | angiotensin antihypertension synthesis: hydrolysis X-ray crystal structure |
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