| 新型免疫调节剂--来氟米特 |
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| 引用本文： | 王荣耕,刘承平,王清海. 新型免疫调节剂--来氟米特[J]. 精细与专用化学品, 2004, 12(23): 10-11 |
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| 作者姓名： | 王荣耕 刘承平 王清海 |
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| 作者单位： | 河北科技大学理学院,河北,石家庄,050018;山东淄博金城实业(集团)股份有限公司化工厂,山东,淄博,255100;石家庄三九利鑫制药有限公司,河北,石家庄,050024 |
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| 摘 要： | 简要介绍了新型免疫调节剂来氟米特--N-(4-三氟甲基苯基)-5-甲基异噁唑-4-甲酰胺的结构和性质;同时对合成来氟米特的中间体5-甲基异噁唑-4-甲酰氯和对三氟甲基苯胺的合成路线进行了概述.通过近年某些国家对来氟米特副作用的论证,分析了可能对来氟米特的应用市场造成一定的影响,进而影响其中间体5-甲基异噁唑-4-甲酰氯和对三氟甲基苯胺的市场.
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| 关 键 词： | 来氟米特 免疫调节剂 5-甲基异噁唑-4-甲酰氯 三氟甲基苯胺 |
| 修稿时间： | 2004-10-25 |
A Novel Immune Regulator:Leflunomide |
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| WANG Rong-geng,LIU Cheng-ping,WANG Qing-hai. A Novel Immune Regulator:Leflunomide[J]. Fine and Specialty Chemicals, 2004, 12(23): 10-11 |
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| Authors: | WANG Rong-geng LIU Cheng-ping WANG Qing-hai |
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| Affiliation: | WANG Rong-geng1,LIU Cheng-ping2,WANG Qing-hai3 |
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| Abstract: | The structure and properties of novel immune regulator leflunomide, N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-formamide, were introduced. Meanwhile, the different routs for synthesizing intermediates: 5-methylisoxazole-4-formyl chloride and trifluoromethyl aniline were summarized. Through the demonstration on side-effect of leflunomide made by some countries recently, the probable impact to application market of leflunomide and to its intermediates could be given. |
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| Keywords: | leflunomide immune regulator 5-methylisoxazole-4-formyl chloride trifluoromethyl aminobenzene |
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