Electrospun Methacrylate-Based Copolymer/Indomethacin Fibers and Their Release Characteristics of Indomethacin |
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| Authors: | Varaporn Pornsopone Pitt Supaphol Ratthapol Rangkupan Supawan Tantayanon |
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| Affiliation: | (1) Petrochemistry and Polymer Science Graduate Program, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand;(2) Technological Center for Electrospun Fibers and Petroleum and Petrochemical College, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand;(3) Metallurgy and Materials Science Research Institute, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand;(4) Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand |
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| Abstract: | Three methacrylate-based copolymers i.e., poly(methacrylic acid-co-methyl methacrylate) (E-L100), poly(ethyl acrylate-co-methyl
methacrylate-co-trimethyl-ammonioethyl methacrylate chloride) (E-RLPO), and poly(butyl methacrylate-co-(2-dimethylaminoethyl)
methacrylate-co-methyl methacrylate) (E-EPO)] were successfully electrospun into fibers, using ethanol (EtOH) as the spinning
solvent. However, electrospinning of these methacrylate-based copolymers and indomethacin (10% by weight of the copolymer)
was only successful when an equivolume of EtOH and ethylacetate (EA) was used as the co-solvent system. The drug-loaded as-spun
copolymeric fibers appeared to be flat, with the size ranging between 1.2 and 2.5 μm. At 24 h, the amount of the drug released
from these drug-loaded as-spun copolymer fibers was about 55%, 30%, and 18% for drug-loaded as-spun E-EPO, E-L100, and E-RLPO
fibers, respectively. |
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| Keywords: | electrospinning methacrylate-based copolymer drug release indomethacin |
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