| C2-对称手性双氨基醇的新合成方法 |
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| 引用本文： | 沈宗旋,周辰刚,周华,张雅文.C2-对称手性双氨基醇的新合成方法[J].化学试剂,2004,26(1):39-40. |
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| 作者姓名： | 沈宗旋 周辰刚 周华 张雅文 |
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| 作者单位： | 苏州大学,化学化工学院,江苏省有机合成重点实验室,江苏,苏州,215006 |
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| 摘 要： | L-脯氨酸经3步反应制得手性氨基醇(2S)-(二苯基羟甲基)四氢吡咯。后者与邻-二(溴甲基)苯反应合成了C2对称手性双氨基醇邻双(2S)-(二苯基羟甲基)四氢吡咯-1-甲基]苯。此合成方法的优点是路线短，操作方便。
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| 关 键 词： | C2对称 手性双氨基醇 邻双[（2S）-（二苯基羟甲基）四氢吡咯-1-甲基]苯 合成 L-脯氨酸 邻-二（溴甲基）苯 |
| 文章编号： | 0258-3283(2004)01-0039-02 |
New approach to C2-symmetric chiral bisaminoalcohol |
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| SHEN Zong-xuan,ZHOU Chen-gang,ZHOU Hua,ZHANG Ya-wen.New approach to C2-symmetric chiral bisaminoalcohol[J].Chemical Reagents,2004,26(1):39-40. |
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| Authors: | SHEN Zong-xuan ZHOU Chen-gang ZHOU Hua ZHANG Ya-wen |
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| Affiliation: | SHEN Zong-xuan,ZHOU Chen-gang,ZHOU Hua,ZHANG Ya-wen * |
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| Abstract: | From L-proline was prepared the chiral aminoalcohol (2S)-(diphenylhydroxymethyl)tetrahydropyrrole via a three-step procedure.Reacting this chiral aminoalcohol with o-bis(bromomethyl)-benzene and triethylamine in anhydrous THF gave the C 2-symmetric chiral bisaminoalcohol o-bis(2S)-(diphenylhydroxymethyl)tetrahydropyrrole-1-yl-methyl]benzene in 37.7% yield.The advantages of this method over previously reported method are the short route and convenient procedure. |
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| Keywords: | C 2-symmetric chiral bisaminoalcohol |
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