Supramolecular Self-Assembled Ligands in Asymmetric Transition Metal Catalysis |
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Authors: | Rosalba Bellini Jarl Ivar van der Vlugt Joost N H Reek |
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Affiliation: | Supramolecular & Homogeneous Catalysis van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam (The Netherlands) |
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Abstract: | The design of novel chiral ligands is at the core of asymmetric catalysis. The catalytic characteristics of a transition metal catalyst such as activity, selectivity and stability can be fine-tuned by optimization of the steric and electronic properties of the coordinating ligands. In asymmetric transformations, catalyst optimization still relies to a large extent on trial-and-error and educated guesses. New strategies based on combinatorial screening and high-throughput experimentation have been introduced for the design and optimization of new ligands and catalytic systems. Supramolecular bidentate ligands that form by self-assembly of building blocks are particularly suited for this combinatorial approach as the potential number of catalysts grows exponentially with the number of building blocks synthesized. Catalytic systems based on supramolecular interactions have proven to be highly advantageous in creating large ligand libraries for high-throughput screening, which allows optimization of activity and selectivity for a variety of reactions. In this review we describe the progress in this field. |
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Keywords: | supramolecular chemistry asymmetric catalysis bidentate ligands monodentate ligands homogeneous catalysis |
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