Bioelectronic Devices Controlled by Biocomputing Systems

This paper outlines recent advances in the integration of enzyme-based biocomputing systems operating as Boolean logic gates and their networks with various bioelectronic devices. “Smart” switchable electrodes for biosensors and biofuel cells with built-in biomolecular logic were designed. Interfacing between the biocomputing systems and switchable electrodes resulted in bioelectronic devices controlled by complex patterns of variable biomolecular signals. Various biomedical applications of the novel logically-controlled bioelectronic devices are feasible.