| 新型氟硼二吡咯纳米粒子荧光探针的合成与性能 |
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| 引用本文： | 尹娟娟,冯彤,薛中博,冯亚青,孟舒献. 新型氟硼二吡咯纳米粒子荧光探针的合成与性能[J]. 化学工业与工程, 2022, 39(1): 19-26. DOI: 10.13353/j.issn.1004.9533.20210123 |
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| 作者姓名： | 尹娟娟 冯彤 薛中博 冯亚青 孟舒献 |
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| 作者单位： | 1. 天津大学化工学院，天津 300350;2. 天津化学化工协同创新中心，天津 300072 |
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| 基金项目： | 国家自然科学基金资助项目（21676187） |
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| 摘 要： | 为了解决氟硼荧类染料(BODIPY)在肿瘤诊断中吸收波长短、水溶性和生物相容性差的问题,设计开发了2种吸收波长达到近红外区的BODIPY分子,并通过与DSPE-PEG2000-MAL-RGD(PC-RGD)自组装形成具有良好水溶性和生物相容性的纳米粒子.研究了纳米粒子的荧光成像能力,结果表明:单取代分子3a和双取代分子...
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| 关 键 词： | BODIPY 纳米粒子 荧光探针 肿瘤诊断 脂质体 |
Synthesis and properties of novel fluoroboron nanoparticle fluorescent probes |
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| YIN Juanjuan,FENG Tong,XUE Zhongbo,FENG Yaqing,MENG Shuxian. Synthesis and properties of novel fluoroboron nanoparticle fluorescent probes[J]. Chemical Industry and Engineering, 2022, 39(1): 19-26. DOI: 10.13353/j.issn.1004.9533.20210123 |
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| Authors: | YIN Juanjuan FENG Tong XUE Zhongbo FENG Yaqing MENG Shuxian |
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| Affiliation: | 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China;2. Collaborative Innovation Center of Chemical Science and Chemical Engineering(Tianjin), Tianjin 300072, China |
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| Abstract: | In order to solve the problem of short absorption wavelength, poor water solubility and poor biocompatibility of Fluoroboron-fluorescent dyes (BODIPY) in tumor diagnosis, two BODIPY molecules with absorption wavelengths reaching the near-infrared region have been designed and synthesized, and they have been combined with DSPE-PEG2000-MAL-RGD (PC-RGD) to form nanoparticles with good water solubility and biocompatibility. Then the fluorescence imaging ability of nanoparticles was studied. The results showed that the fluorescence emission wavelengths of the mono-substituted molecule 3a and the di-substituted molecule 3b reached 650 and 775 nm, respectively. And di-substituted molecule 3b shows greater Stokes shift than 3a due to its higher degree of conjugation. Moreover, the encapsulated nanoparticles show good water solubility and biocompatibility, which provides a possibility as fluorescent probes for tumor diagnosis. |
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| Keywords: | fluoroboron-fluorescent dyes (BODIPY)； nanoparticles； fluorescent probe； tumor diagnosis； liposome |
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