Preparation and characterization of novel bioactive dicalcium silicate ceramics |
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| Affiliation: | 1. Departamento de Cerámica, Instituto de Cerámica y Vidrio, C/ Kelsen 5. Campus de Cantoblanco, 28049 Madrid Spain;2. Instituto de Bioingenieria, Universidad Miguel Hernández, Avda. de la Universidad s/n, 03202 Elche, Alicante Spain;1. Chinese Academy of Sciences Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, People''s Republic of China;2. Department of Materials Science and Engineering, University of Ioannina, GR-451 10, Ioannina, Greece;3. Key Laboratory of Quantum Information, School of Physical Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, People''s Republic of China;1. Dipartimento di Ingegneria Industriale, University of Padova, Via Marzolo, 9, 35131 Padova, Italy;2. Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK;3. Institute of Biomedical Engineering, Imperial College London, South Kensington Campus, SW7 2AZ London, UK;4. Department of Bioengineering, Imperial College London, South Kensington Campus, SW7 2AZ London, UK;1. Department of Ophthalmology, the Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou 310009, China;2. Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China;3. Zhejiang Province׳s Key Laboratory of 3D Printing Process and Equipment, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | The beta- and gamma-dicalcium silicate (β- and γ-Ca2SiO4) ceramics were prepared by sintering β-Ca2SiO4 greens at 1100, 1300, and 1450 °C, respectively, after compacting with cold isostatic pressure. The phase transition from β- to γ-phase of polymorphic ceramics occurred at 1100–1300 °C. Bending strength and Vickers hardness of β-Ca2SiO4 ceramic sintered at 1100 °C were only 25.6 ± 3.8 MPa and 0.41 ± 0.05 GPa. In contrast, the mechanical properties of the γ-Ca2SiO4 were improved remarkably when the ceramics were sintered at 1450 °C, corresponding to bending strength, 97.1 ± 6.7 MPa; Vickers hardness, 4.34 ± 0.35 GPa, respectively. The ceramics were soaked in the simulated body fluid (SBF) for various periods were characterized by SEM, XRD, FTIR, and EDS analysis, and the results indicated that the carbonated hydroxyapatite (CHA) was formed on the surface of the ceramics within 3 days. In addition, cell attachment assay showed that the ceramics supported the mesenchymal stem cells adhesion and spreading, and the cells established close contacts with the ceramics after 1 day of culture. These findings indicate that the γ-Ca2SiO4 ceramic possesses good bioactivity, biocompatibility and mechanical properties, and might be a promising bone implant material. |
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