Long-term effects of tear film component deposition on the surface and optical properties of two different orthokeratology lenses |
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| Affiliation: | 1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology. 1, Sec. 3, Zhongxiao E. Rd., Taipei 10608, Taiwan;2. Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Taoyuan 333, Taiwan;3. College of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Taoyuan 333, Taiwan;4. Research and Development Center, Brighten Optix Co., 6F-1, No. 150, Sec.4, Chengde Rd., Shilin Dist., Taipei 111, Taiwan;5. Department of Optometry, University of Kang Ning, No. 137, Alley 75, Sec. 3, Kang Ning Road, Neihu District, Taipei 11485, Taiwan;6. Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan;1. Brien Holden Institute of Optometry and Vision Sciences, L V Prasad Eye Institute, Road no. 2, Banjara Hills, Hyderabad 500034, Telangana, India;2. Prof Brien Holden Eye Research Centre, L V Prasad Eye Institute, Road no. 2, Banjara Hills, Hyderabad 500034, Telangana, India;3. Bausch & Lomb Contact Lens Centre, L V Prasad Eye Institute, Road no. 2, Banjara Hills, Hyderabad 500034, Telangana, India;1. ELZA Institute, Dietikon, Switzerland;2. Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil;3. Faculty of Medicine, University of Geneva, Geneva, Switzerland;4. School of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium;5. School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China;6. USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA;7. University of Zurich, CABMM, Laboratory for Ocular Cell Biology Group, Zurich, Switzerland;1. Department of Ophthalmology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;2. Department of Ophthalmology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China;1. Department of Applied Physics, University of Zaragoza, Zaragoza, Spain;2. Natural Optics Balaguer, Lleida, Spain;3. QVision, Almeria, Spain;4. Óptica Ronda, Almería, Spain;5. Óptica Julio Ezpeleta, Pamplona, Spain;6. Department of Ophthalmology, Vithas Medimar International Hospital, 03016 Alicante, Spain;7. Department of Optics, Pharmacology, and Anatomy, University of Alicante, Spain |
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| Abstract: | PurposeTo understand the effects of long-term deposition of tear film components on the surface and optical properties of orthokeratology (ortho-k) lenses, two different lenses, Brighten 22 and Optimum Extra, were tested here.MethodsOrtho-k lenses were immersed in artificial tears and cleaned with a commercial care solution repeatedly for up to 90 days. Both the daily and accumulated lysozyme deposition amounts using an Enzyme-Linked ImmunoSorbent Assay were then analyzed. The base curve, central thickness, power, and transmission of visible light, ultraviolet A, and ultraviolet B were analyzed before and after repeated tear film component deposition procedures. The surface roughness using atomic force microscopy was observed and an energy dispersive spectrometer was used to analyze the composition of the deposits.ResultsThe highest levels of lysozyme were adsorbed on both lens materials during the first four days of the procedure and became saturated by day 6. For both lens materials, contamination on the lenses was easily observed by day 30, and the degree of surface roughness was higher. The transmission levels of different light spectrums were reduced showing that the optical characteristics of both lenses were also affected.ConclusionsThe results provide in vitro evidence that lysozyme could not be completely removed from orthokeratology lenses. Both surface and optical properties were affected by the deposition of tear film components. However, only one commercial multipurpose care solution was used to clean the lens in this study when the main ingredient was a surfactant, and the results might be different when other care regimens with other key ingredients are used. In addition, whether tear film component deposition might result in increased risks of infection or corneal abrasion will require further investigation. |
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| Keywords: | Orthokeratology lens Lysozyme Tear film components Surface roughness Optical property |
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