Development of flurbiprofen-loaded nanoparticles with a narrow size distribution using sucrose |
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Authors: | Dong Hoon Oh Yi-Dong Yan Dong Wuk Kim Jong Oh Kim Chul Soon Yong |
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Affiliation: | 1. College of Pharmacy, Yeungnam UniversityDae-Dong, GyongsanSouth Korea;2. College of Pharmacy, Hanyang UniversitySangnok-gu, AnsanSouth Korea |
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Abstract: | Objective: A novel flurbiprofen-loaded nanoemulsion which gave uniform emulsion droplets with a narrow size distribution was previously reported to be prepared using membrane emulsification method. The purpose of this study is to develop a novel flurbiprofen-loaded nanoparticle with a narrow size distribution and improved bioavailability.Method: The nanoparticle was prepared by solidifying nanoemulsion using sucrose as a carrier via spray drying method. Its physicochemical properties were investigated using SEM, DSC and PXRD. Furthermore, dissolution and bioavailability in rats were evaluated compared to a flurbiprofen-loaded commercial product.Results: The flurbiprofen-loaded nanoparticles with flurbiprofen/sucrose/surfactant mixture (1/20/2, weight ratio) gave good solidification and no stickiness. They associated with about 70?000-fold improved drug solubility and had a mean size of about 300 nm with a narrow size distribution. Flurbiprofen was present in a changed amorphous state in these nanoparticles. Moreover, the nanoparticles gave significantly shorter Tmax, and higher AUC and Cmax of the drug compared to the commercial product (p?0.05). In particular, they showed about nine-fold higher AUC of the drug than did the commercial productConclusion: These flurbiprofen-loaded nanoparticles prepared with sucrose by the membrane emulsification and spray drying method would be a potential candidate for orally delivering poorly water-soluble flurbiprofen with enhanced bioavailability. |
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Keywords: | Flurbiprofen membrane emulsification nanoparticle narrow size distribution spray drying sucrose |
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