Characterization of micellar systems produced by new amphiphilic conjugates of poly(ethylene glycol) |
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| Authors: | R Pignatello V Pantò L Basile A Leonardi C Guarino C La Rosa |
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| Affiliation: | 1. Sezione di Tecnologia Farmaceutica, Dipartimento di Scienze del Farmaco, Università degli Studi di Catania – Viale A. Doria
CataniaItaly;2. EtnaLead srl, via San Nullo
CataniaItaly;3. Centro Nazionale ONDICO, Istituto Superiore di Sanità – viale Regina Elena
RomaItaly;4. Dipartimento di Scienze Chimiche, Università degli Studi di Catania – Viale A. Doria
CataniaItaly |
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| Abstract: | This study proposes polymeric micelles produced using new amphiphilic conjugates between amino- or carboxy-mPEG2000 and three different α-lipoamino acids (PEG-LAA). The characterization of these colloidal systems showed CMC values, in the order of 10?5?M, that are interesting in the view of an in vivo administration. The PEG-LAA micelles also showed a good stability at 37?°C and upon dilution in aqueous media. Using a colored probe as a model lipophilic compound, the loading efficiency and in vitro release profile were also outlined. |
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| Keywords: | CMC conductimetry lipoamino acids micelles |
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