Initial and follow-up brain MRI findings and correlation with the clinical course in Wilson's disease |
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Authors: | JK Roh TG Lee BA Wie SB Lee SH Park KH Chang |
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Affiliation: | Department of Neurology, Seoul National University, College of Medicine, Republic of Korea. |
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Abstract: | We performed pretreatment brain MRIs in 25 patients with neurologically symptomatic Wilson's disease (WD) and clinical and MRI follow-up in 16 of them. All 25 pretreatment MRIs revealed abnormalities, with abnormal high-signal intensity (HSI) in bilateral thalami being the most common (92%). HSI lesions in the brainstem (84%) and the basal ganglia (72%) were also common. Brain atrophy was present in 88% of the 25 patients. In the follow-up period of 5 to 24 months, during which the patients were treated with D-penicillamine, both HSI lesions and neurologic symptoms improved in 88% of the 16 patients, but the brain atrophy did not change. |
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