Attenuation of experimental autoimmune neuritis in the Lewis rat by treatment with an antibody to L-selectin |
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Authors: | JJ Archelos T Fortw?ngler HP Hartung |
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Affiliation: | Department of Neurology, Julius-Maximilians-Universit?t Würzburg, Germany. archelos@mpipsykl.mpg.de |
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Abstract: | The leukocyte adhesion molecule L-selectin plays a key role in the initial steps of transendothelial migration of T cells and monocytes. In this study we investigated the role of L-selectin in the pathogenesis of experimental autoimmune neuritis (EAN) an animal model of the Guillain-Barré syndrome. EAN was induced in Lewis rats by sensitization with peripheral nerve myelin. Treatment with HRL3, a monoclonal antibody to L-selectin, efficiently suppressed clinical signs of EAN. Histological examination of the peripheral nervous system (PNS) revealed a marked reduction of inflammatory infiltrates and demyelination during treatment with HRL3. We conclude that L-selectin-dependent mechanisms are of pathophysiological relevance in EAN. Modulation of L-selectin in vivo could be a novel therapeutic approach to autoimmune diseases of the PNS. |
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