| 2,3-二氟-4-羟基苯硼酸的合成 |
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| 引用本文： | 张保玲,原丽平,侯彩英,耿向东. 2,3-二氟-4-羟基苯硼酸的合成[J]. 化学工程师, 2010, 24(7): 8-9,16 |
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| 作者姓名： | 张保玲 原丽平 侯彩英 耿向东 |
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| 作者单位： | 山西省应用化学研究所,山西,太原030028 |
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| 摘 要： | 本文以邻二氟苯为原料,利用其定位效应,通过与丁基锂、硼酸三甲酯直接作用得到2,3-二氟苯硼酸,再通过与H2O2反应得到2,3-二氟苯酚。以所合成的2,3-二氟苯酚为原料,通过叔丁基二甲基氯硅烷保护酚羟基,再在低温下与丁基锂、硼酸三甲酯等作用得到2,3-二氟-4-羟基苯硼酸,5步反应总产率为83%。
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| 关 键 词： | 邻二氟苯 邻二氟苯衍生物 2 3-二氟-4-羟基苯硼酸 |
Synthesis of 2,3-difluoro-4-hydroxybenzene boronic acid |
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| ZHANG Bao-ling,YUAN Li-ping,HOU Cai-ying,GENG Xiang-dong. Synthesis of 2,3-difluoro-4-hydroxybenzene boronic acid[J]. Chemical Engineer, 2010, 24(7): 8-9,16 |
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| Authors: | ZHANG Bao-ling YUAN Li-ping HOU Cai-ying GENG Xiang-dong |
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| Affiliation: | ( Shanxi Institute of Applied Chemistry, Taiyuan 030028, China) |
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| Abstract: | 2,3-Difluorophenol was prepared from hydrogen peroxide and 2,3-difluoro-benezne boronic acid, the latter was synthesized from 1,2-difuorobenzene, butyl lithium and trimethyl borate using the orientation effect of 1,2-difluorobenzene. 2,3-difluoro-4-hydroxybenzene boronic acid was obtained with 2,3-difluorophenol as starting material by three steps：first protect the phenolic hydroxyl group via t-butyldimethylsilyl chloride; subsequently react with butyl lithium and trimethyl borate; and finally deprotect to gain the final product. The total yield of five steps was 63%. |
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| Keywords: | 1,2--difuorobenzene derivatives of 1,2 -difuorobenzene 2,3-difluoro-4 -hydroxybenzene boronic acid |
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