| 红曲霉固态发酵产洛伐他汀的响应面优化 |
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| 引用本文： | 郑虹.红曲霉固态发酵产洛伐他汀的响应面优化[J].中国酿造,2014(10):76-80. |
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| 作者姓名： | 郑虹 |
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| 作者单位： | 福建师范大学福清分校海洋与生化工程学院; |
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| 基金项目： | 福建师范大学福清分校省级重点学科建设基金项目(20120326) |
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| 摘 要： | 采用Box-Benhnken试验设计和响应面分析,对红曲霉固态发酵产洛伐他汀的工艺条件进行优化,得到最佳的发酵工艺条件为培养时间、初始含水量和大米装量分别为17 d、25.4%、53.3 g/250 mL,在此条件下,洛伐他汀的产量可达15.35 mg/g,与预测值（14.73 mg/g）较为接近。结果表明响应面法优化红曲霉固态发酵产洛伐他汀的条件合理可行。
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| 关 键 词： | 红曲霉 洛伐他汀 固态发酵 响应面分析 |
Optimization of solid-state fermentation conditions of Monascus for lovastatin production by response surface methodology |
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| ZHENG Hong.Optimization of solid-state fermentation conditions of Monascus for lovastatin production by response surface methodology[J].China Brewing,2014(10):76-80. |
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| Authors: | ZHENG Hong |
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| Affiliation: | ZHENG Hong (School of Ocean Science and Biochemistry Engineering, Fuqing Branch of Fujian Normal UniversitY, Fuqing 350300, China) |
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| Abstract: | In order to optimize the solid-state fermentation of Monascus for lovastatin production response surface methodology（RSM） and BoxBehnken design analysis was employed. The results showed that the optimized conditions were fermentation time 17 d, initial water content 25.4%,and rice content 53.3 g/250 ml. Under this condition, the highest lovastatin production was 15.35 mg/g, close to the predicted value 14.73 mg/g. This study proved that RSM could be efficiently applied in optimizing the solid-state fermentation conditions of Monascus for lovastatin production. |
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| Keywords: | Monascus lovastatin solid-state response surface methodology |
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