| (S)-(-)-4-[反式-4’-(反式-4”-丙基环己基)-环己基]-1-(1-甲基庚氧基)-2,6-二氟苯的合成 |
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| 引用本文： | 李辉,杜渭松,李建.(S)-(-)-4-[反式-4’-(反式-4”-丙基环己基)-环己基]-1-(1-甲基庚氧基)-2,6-二氟苯的合成[J].应用化工,2009,38(5). |
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| 作者姓名： | 李辉 杜渭松 李建 |
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| 作者单位： | 西安近代化学研究所,光电材料事业部,陕西,西安,710065 |
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| 摘 要： | 报道了手性添加剂(S)-(-)-4-反式-4’-(反式-4"-丙基环己基)-环己基]-1-(1-甲基庚氧基)-2,6-二氟苯的合成方法,通过格氏偶联、硫酸氢钾催化脱水、催化氢化、顺反异构化、超低温反应、双氧水氧化、M itsunobu成醚反应共7步反应合成了目标产物,总收率21%。经IR、MS、1H NMR鉴定,结构正确,并测定了其扭曲力。
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| 关 键 词： | 手性添加剂 合成 异构化 扭曲力 |
Synthesis of (S)-(-)-4-[trans-4'-(trans-4"-propylcyclohexyl)-cyclohexyl]-1-(1-methylheptyloxy)-2,6-difluorbenzol |
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| LI Hui,DU Wei-song,LI Jian.Synthesis of (S)-(-)-4-[trans-4'-(trans-4"-propylcyclohexyl)-cyclohexyl]-1-(1-methylheptyloxy)-2,6-difluorbenzol[J].Applied chemical industry,2009,38(5). |
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| Authors: | LI Hui DU Wei-song LI Jian |
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| Abstract: | The synthetic method of(S)-(-)-4-trans-4'-(trans-4"-propylcyclohexyl)-cyclohexyl]-1-(1-methylheptyloxy)-2,6-difluorbenzol is reported.The target compound was synthesized through seven steps reactions include grignard coupling,dehydration,hydrogenation,isomerization,ultra low temperature reaction,oxidation and Mitsunobu etherification.The total yield is 21%.Structure identification was performed by IR,MS,1H NMR.The helix twisting power is measured. |
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| Keywords: | chiral dopants synthesis isomerization helix twisting power |
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