Effect of age and α-linolenic acid deficiency on Δ6 desaturase activity and liver lipids in rats |
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Authors: | T K L Dinh J M Bourre G Durand |
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Affiliation: | (1) Laboratoire de Nutrition et de Sécurité Alimentaire, INRA, 78352 Jouy-en-Josas Cédex;(2) Laboratoire de Neurotoxicologie, INSERM U26, 75010 Paris, France |
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Abstract: | The combined effects of age and of diet deficient in n−3 fatty acids on Δ6 desaturation of linoleic acid and on lipid fatty
acid composition were studied in the liver of the rat at 2, 6, 12, 18 and 24 mon of age. The profiles of Δ6 desaturase activity
and fatty acid composition were studied in the deficient rats refed, at these different ages either with 18∶3n−3 (mixture
of peanut and rapeseed oils) or with 20∶5n−3+22∶6n−3 (fish oil) diets for 2, 4, 8 or 12 wk. Results showed that the liver
Δ6 desaturation activity in the control rats remained high at 2 and 6 mon, decreased by 30% from 6 to 12 mon, and then remained
stable from 12 to 24 mon. In the deficient rats, this activity remained high during the entire period studied. Thus, the profile
of liver Δ6 desaturase activity after puberty was not related to age only; it also depended on the polyunsaturated fatty acid
(PUFA) n−6 and n−3 balance in the diet. In the controls, in parallel with the Δ6 desaturase activity, PUFA metabolism could
be divided into three periods: a “young” period, and “old age” period, separated by a period of transition between 6 and 12
mon. Recovery from PUFA n−3 deficiency occurred at all ages but in a different manner depending on whether the rats were “young”
or “old”. Recovery was faster if long-chain n−3 PUFA rather than α-linolenic acid were supplied in the diet. |
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