| 双嘧达莫和腺苷-磷酸对照射小鼠免疫功能的影响 |
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| 引用本文： | 卜桂兰,朴春姬,金玉珂.双嘧达莫和腺苷-磷酸对照射小鼠免疫功能的影响[J].辐射研究与辐射工艺学报,2000,18(4):304-307. |
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| 作者姓名： | 卜桂兰 朴春姬 金玉珂 |
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| 作者单位： | 白求恩医科大学放射医学研究所,长春,130021 |
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| 摘 要： | 研究了预先给予双嘧达莫（ＤＰ）和腺苷－磷酸（ＡＭＰ）对不同剂量Ｘ射线照射小鼠免疫功能的影响。采用ＢＡＬＢ／Ｃ纯系小鼠给予一次性不同剂量（０、１、２、４Ｇｙ）Ｘ射线照射。照射前给予ＤＰ２ｍｇ和ＡＭＰ５ｍｇ，检测胸腺细胞自发增殖反应能力和脾细胞对ＣｏｎＡ的增殖反应能力的变化。结果表明：单纯给予ＤＰ＋ＡＭＰ组胸腺自发增殖反应能力和脾细胞对ＣｏｎＡ的增殖反应能力较对照组明显下降，但１Ｇｙ和２ＧｙＸ射线照射前预先给予ＤＰ和ＡＭＰ能显著增强小鼠胸腺自发增殖反应能力和脾淋巴细胞对ＣｏｎＡ诱导的增殖反应能力。
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| 关 键 词： | 双嘧达莫 腺苷－磷酸 辐射 免疫功能 抗辐射药物 |
THE EFFECTS OF DP AND AMP ON IMMUNE FUNCTIONS IN IRRADIATED MICE |
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| BU Guilan,PIAO Chunji,JIN Yuke.THE EFFECTS OF DP AND AMP ON IMMUNE FUNCTIONS IN IRRADIATED MICE[J].Journal of Radiation Research and Radiation Processing,2000,18(4):304-307. |
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| Authors: | BU Guilan PIAO Chunji JIN Yuke |
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| Abstract: | The effects of DP and AMP on the immune function in X-ray irradiated mice with different doses were studied in this dissertation.Mice(BALB/C) were irradiated with different doses(0,1,2,4Gy) of X-rays.The spontanous proliferation of thymocytes and ConA-induced proliferation reaction of splenocytes in mice pretreated with DP(2mg) and AMP(5mg) were detected. The results were as follows:the spontanous proliferation of the thymocytes and the ConA-induced proliferation reaction of splenocytes in mice injected with DP and AMP decreased markdely, but increased significantly in mice treated with DP and AMP prior to irradiation by 1Gy and 2Gy X-rays. |
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| Keywords: | DP AMP Ionizing radiation Immune function |
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