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Mechanical and tribological properties of poly(hydroxyethyl methacrylate) hydrogels as articular cartilage substitutes |
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| Authors: | L Bostan A-M Trunfio-Sfarghiu L VerestiucMI Popa F MunteanuJ-P Rieu Y Berthier |
| Affiliation: | a University of Lyon, Contact and Structural Mechanics Laboratory, CNRS INSA-Lyon, UMR5259, F-69621 Villeurbanne Cedex, France b “Gheorghe Asachi” Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Iasi, Romania c “Gr.T.Popa” University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Iasi, Romania d University of Lyon, CNRS, Claude Bernard Lyon 1 University, Laboratory of Nanostructures and Physics of the Condensed Materials, UMR5586, F-69622 Villeurbanne Cedex, France |
| Abstract: | Poly(hydroxyethyl methacrylate) (p(HEMA)) hydrogels have been proposed as promising biomaterials to replace damaged articular cartilage. A major obstacle to their use as replacement bearing tissue is their poor mechanical properties in comparison with healthy articular cartilage. The purpose of this study was to obtain p(HEMA) hydrogels with physicochemical and mechanical properties close to healthy articular cartilage, by introducing a hydrophilic monomer, namely acrylic acid (AA). Formulations of hydrogels with different amounts of hydrophilic monomer (acrylic acid, AA) were synthesized and tested: p(HEMA), p(HEMA-co-5%AA), p(HEMA-co-25%AA). The macro-mechanical tests were reproduced at nanoscale in order to verify if the superficial properties of the hydrogels are similar to the bulk ones. |
| Keywords: | Hydrogel p(HEMA) Articular cartilage Mechanical properties |
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