Biologic potential of calcium phosphate biopowders produced via decomposition combustion synthesis |
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| Affiliation: | 1. George S. Ansell Department of Metallurgy and Materials Engineering, Colorado School of Mines, 1500 Illinois Street, Golden, CO 80401, USA;2. University of Colorado School of Medicine, Department of Orthopaedics, Aurora, CO 80045, USA;1. Department of Materials Science and Engineering, National Cheng Kung University, Tainan City 70101, Taiwan;2. Research Center for Energy Technology and Strategy, National Cheng Kung University, Tainan City 70101, Taiwan;3. Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan City 70101, Taiwan;1. Facultad de Ciencias Químicas-UASLP, 5 Av. Nava, 78210 San Luis Potosí, México;2. Instituto de Metalurgia-UASLP, 550 Sierra Leona, CP 78216 San Luis Potosí, México;1. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze street, Novosibirsk 630128, Russia;2. Novosibirsk State University, 2 Pirogova street, Novosibirsk 630090, Russia;3. SRC VB “VECTOR”, Koltsovo, Novosibirsk region 630559, Russia;4. Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, Russia;1. Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, China;2. State Grid of China Technology College, Jinan 250002, China |
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| Abstract: | The aim of this research was to evaluate the biologic potential of calcium phosphate (CaP) biopowders produced with a novel reaction synthesis system. Decomposition combustion synthesis (DCS) is a modified combustion synthesis method capable of producing CaP powders for use in bone tissue engineering applications. During DCS, the stoichiometric ratio of reactant salt to fuel was adjusted to alter product chemistry and morphology. In vitro testing methods were utilized to determine the effects of controlling product composition on cytotoxicity, proliferation, biocompatibility and biomineralization. In vitro, human fetal osteoblasts (ATCC, CRL-11372) cultured with CaP powder displayed a flattened morphology, and uniformly encompassed the CaP particulates. Matrix vesicles containing calcium and phosphorous budded from the osteoblast cells. CaP powders produced via DCS are a source of biologically active, synthetic, bone graft substitute materials. |
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| Keywords: | Decomposition combustion synthesis Bone tissue engineering Calcium phosphate Bioactivity Osteoblasts |
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