Synthesis and in vitro bioactivity assessment of injectable bioglass?organic pastes for bone tissue repair |
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| Affiliation: | 1. Department of Materials and Ceramic Engineering, CICECO, 3810-193 Aveiro, Portugal;2. Turin Polytechnic University in Tashkent, 17, Niyazova, 100095 Tashkent, Uzbekistan;3. Department of Inorganic Chemistry III, University of Bayreuth, 95440 Bayreuth, Germany;4. Technische Universität Darmstadt Institute for Materials Science, Jovanka-Bontschits-Strasse 2, D-64287 Darmstadt, Germany;1. Shenzhen Key Laboratory of Special Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, PR China;2. Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, PR China;3. Department of Applied Physics, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR;4. Department of Manufacturing and Materials, Cranfield University, Cranfield, Bedfordshire, MK43 0AL, United Kingdom;5. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, Hubei, PR China;6. State Key Laboratory of Solidification Processing School of Materials Science and Engineering Northwestern Polytechnical University, Xi’an 710072, PR China;1. Dep. Eng. Metalúrgica e de Materiais, Universidade Federal do Ceará, Campus do Pici Bloco 714, 60455-760 Fortaleza, CE, Brazil;2. Institut Català de Nanociència i Nanotecnologia, Campus de la UAB, Edifici ICN2 08193 Bellaterra, BCN, Spain;1. Ceramic Department, Materials and Energy Research Center, Alborz, Iran;2. Semiconductor Department, Materials and Energy Research Center, Alborz, Iran |
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| Abstract: | The aim of this work was to study the bioactivity of systems based on a clinically tested bioactive glass (BG) particulates (mol%: 4.33 Na2O?30.30 CaO?12.99 MgO?45.45 SiO2?2.60 P2O5?4.33 CaF2) and organic carriers. The cohesiveness of injectable bone graft products is of high relevance when filling complex volumetric bone defects. With this motivation behind, BG particulates with mean sizes within 11?14 μm were mixed in different proportions with glycerol (G) and polyethylene glycol (PEG) as organic carriers and the mixtures were fully injectable exhibiting Newtonian flow behaviors. The apatite forming ability was investigated using X-ray diffraction and field emission scanning electron microscopy under secondary electron mode after immersion of samples in simulated body fluid (SBF) for time durations varying between 12 h and 7 days. The results obtained revealed that in spite of the good adhesion of glycerol and PEG carriers to glass particles during preparation stage, they did not hinder the exposure of bioactive glass particulates to the direct contact with SBF solution. The results confirmed the excellent bioactivity in vitro for all compositions expressed by high biomineralization rates with the formation of crystalline hydroxyapatite being identified by XRD after 12 h of immersion in SBF solution. |
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| Keywords: | Bioactive glasses Organic carriers XRD SEM Bone grafts |
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