A study of metabolites isolated from the urine samples of cats and dogs administered orbifloxacin |
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Authors: | S Matsumoto M Takahashi N Kitadai H Katae |
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Affiliation: | Research Laboratories, Animal Science Division, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan. |
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Abstract: | Urine samples of cats and dogs collected for 24 hr after a subcutaneous injection of orbifloxacin (OBFX) were analyzed. The metabolites were examined using HPLC. In the dog urine, 87% of total was the parent compound and 13% glucuronide compound of OBFX and 96% was parent and 4% metabolite in the cat urine. The metabolite of cat urine was identified as N-hydroxy OBFX, determined by comparison of the extraction of urine with chloroform with the standard compound of N-hydroxy OBFX, using LC/APCIMS. N-hydroxy OBFX had a weaker antibacterial activity against fluoroquinolone sensitive bacteria than the parent compound. |
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