| 分散固相萃取-超高效液相色谱串联质谱法测定 牛肉中7种头孢菌素类药物及其代谢物 |
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| 引用本文： | 崔凤云,张朝晖,李建辉,黄华,严华,云环,刘鑫,齐鹤鸣,何悦,许翔.分散固相萃取-超高效液相色谱串联质谱法测定 牛肉中7种头孢菌素类药物及其代谢物[J].食品安全质量检测技术,2016,7(2):575-583. |
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| 作者姓名： | 崔凤云 张朝晖 李建辉 黄华 严华 云环 刘鑫 齐鹤鸣 何悦 许翔 |
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| 作者单位： | 北京出入境检验检疫局检验检疫技术中心,北京出入境检验检疫局检验检疫技术中心,北京出入境检验检疫局检验检疫技术中心,北京市食品安全监控和风险评估中心,北京出入境检验检疫局检验检疫技术中心,北京出入境检验检疫局检验检疫技术中心,北京出入境检验检疫局检验检疫技术中心,北京出入境检验检疫局检验检疫技术中心,北京出入境检验检疫局检验检疫技术中心,北京出入境检验检疫局检验检疫技术中心 |
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| 基金项目： | 北京市科技计划项目(Z141100002614020)、北京国检局科技计划项目(2015BK021) |
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| 摘 要： | 目的建立分散固相萃取超高效液相色谱-串联质谱法(dispersion solid-phase extraction with ultra-performance liquid chromatography-tandem mass spectrometry,DSPE-UPLC-MS/MS)同时测定牛肉中7种头孢菌素类药物及其代谢物残留量的方法。方法样品经乙腈-水溶液提取,C_(18)分散固相萃取净化,在电喷雾正离子多反应监测模式下进行定量和定性分析。结果 7种头孢菌素类药物及其代谢物的方法检出限和定量限分别为0.4~0.8μg/kg和1.1~2.3μg/kg。在3个添加浓度水平的平均回收率为68.3%~95.7%,相对标准偏差为1.9%~12.5%。结论该方法快速、准确、灵敏、稳定,能够满足牛肉中头孢菌素类药物残留的检测。
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| 关 键 词： | 头孢菌素类药物 分散固相萃取 超高效液相色谱-串联质谱 牛肉 |
| 收稿时间： | 2015/11/5 0:00:00 |
| 修稿时间： | 2016/1/31 0:00:00 |
Determination of 7 kinds of cephalosporins and its metabolites in beef by dispersion solid-phase extraction with ultra-performance liquid chromato-graphy-tandem mass spectrometry |
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| CUI Feng-Yun,ZHANG Zhao-Hui,LI Jian-Hui,HUANG Hu,YAN Hu,YUN Huan,LIU Xin,QI He-Ming,HE Yue and XU Xiang.Determination of 7 kinds of cephalosporins and its metabolites in beef by dispersion solid-phase extraction with ultra-performance liquid chromato-graphy-tandem mass spectrometry[J].Food Safety and Quality Detection Technology,2016,7(2):575-583. |
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| Authors: | CUI Feng-Yun ZHANG Zhao-Hui LI Jian-Hui HUANG Hu YAN Hu YUN Huan LIU Xin QI He-Ming HE Yue and XU Xiang |
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| Affiliation: | Beijing Inspection and Quarantine Testing Center,Beijing Entry-Exit Inspection and Quarantine Bureau,Beijing Inspection and Quarantine Testing Center,Beijing Entry-Exit Inspection and Quarantine Bureau,Beijing Inspection and Quarantine Testing Center,Beijing Entry-Exit Inspection and Quarantine Bureau,Beijing Municipal Center for Food Safety Monitoring and Risk Assessment,Beijing Inspection and Quarantine Testing Center,Beijing Entry-Exit Inspection and Quarantine Bureau,Beijing Inspection and Quarantine Testing Center,Beijing Entry-Exit Inspection and Quarantine Bureau,Beijing Inspection and Quarantine Testing Center,Beijing Entry-Exit Inspection and Quarantine Bureau,Beijing Inspection and Quarantine Testing Center,Beijing Entry-Exit Inspection and Quarantine Bureau,Beijing Inspection and Quarantine Testing Center,Beijing Entry-Exit Inspection and Quarantine Bureau,Beijing Inspection and Quarantine Testing Center,Beijing Entry-Exit Inspection and Quarantine Bureau |
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| Abstract: | |
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| Keywords: | cephalosporin drugs dispersion solid-phase extraction ultra-performance liquid chromatography-tandem mass spectrometry beef |
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