Effect of metabolites of 7,12-dimethylbenz(a)anthracene on the dynamics of its fluorescence in the skin of hairless mice

The influence of two metabolites of 7,12-dimethylbenz(a)anthracene (DMBA)--7-hydromethyl-12-methylbenz(a)anthracene and 7,12-dihydroxymethylbenz(a)anthracene--on the dynamics of DMBA fluorescence was studied in the skin of mice. The first of the metabolites did not affect the dynamics of DMBA fluorescence, whereas the second one, when used in equimolar concentrations with DMBA, prolonged the duration of DMBA fluorescence in the skin. The same effect was observed in case of 7,8-benzoflavone, and inhibitor of DMBA metabolism.