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Integrin-Targeted,Short Interfering RNA Nanocomplexes for Neuroblastoma Tumor-Specific Delivery Achieve MYCN Silencing with Improved Survival
Authors:Aristides D Tagalakis  Vignesh Jayarajan  Ruhina Maeshima  Kin H Ho  Farhatullah Syed  Lin-Ping Wu  Ahmad M Aldossary  Mustafa M Munye  Talisa Mistry  Olumide Kayode Ogunbiyi  Arturo Sala  Joseph F Standing  Seyed M Moghimi  Andrew W Stoker  Stephen L Hart
Affiliation:1. Department of Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH UK;2. Department of Inflammation, Infection and Immunity, UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH UK;3. Centre for Pharmaceutical Nanotechnology and Nanotoxicology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100 Denmark;4. Department of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH UK;5. Department of Life Sciences, Brunel University London, Kingston Lane, Middlesex, UB8 3PH UK;6. Department of Developmental Biology and Cancer, UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH UK
Abstract:
Keywords:MYCN  neuroblastomas  siRNA  tumor-specific delivery  tumors
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