Poly(ionic liquid)/Ce-Based Antimicrobial Nanofibrous Membrane for Blocking Drug-Resistance Dissemination from MRSA-Infected Wounds |
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Authors: | Zhenhong Luo Hengqing Cui Jiangna Guo Jieran Yao Xia Fang Feng Yan Bin Wang Hailei Mao |
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Affiliation: | 1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 China;2. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011 China;3. Department of Anesthesiology and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032 China |
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Abstract: | Resistant bacteria have become a global threat. Even if bacteria are killed, their carried drug-resistant genes can remain in the environment and spread to other microbes via horizontal gene transfer. Development of antimicrobial materials with intrinsic gene break down activity can prevent the dissemination of released drug-resistant genes from the dead bacteria. Herein, imidazolium type poly(ionic liquid) (PIL)/cerium (IV) ion-based electrospun nanofibrous membranes (PIL-Ce) are synthesized. The effects of PIL and Ce moieties on the antimicrobial properties against Gram-negative Escherichia coli and kanamycin-resistant E. coli, and Gram-positive Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), as well as deoxyribonuclease-mimic activities to the drug-resistant genes of KanR (E. coli) and mecA (MRSA) are investigated. The Ce-containing PIL membranes show the high efficiencies to eradicate bacteria and disintegrate drug-resistant genes. A wound treatment test using MRSA infected mice as the model further demonstrate that PIL-Ce membranes combine both antibacterial and DNase-mimic properties, and may have the potential application as a new “green” wound dressing to block the drug resistance spread in a clinical setting. |
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Keywords: | antimicrobial nanofibers artificial enzyme bacterial resistance DNA cleavage poly(ionic liquid) |
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