Near-Infrared Light Triggered Silk Fibroin Scaffold for Photothermal Therapy and Tissue Repair of Bone Tumors |
| |
| Authors: | Hao Miao Runqing Shen Wenhai Zhang Zaifu Lin Hao Wang Likun Yang Xiang-Yang Liu Naibo Lin |
| |
| Affiliation: | 1. College of Materials, Research Institution for Biomimetics and Soft Matter, Fujian Key Provincial Laboratory for Soft Functional Materials Research, Xiamen University, 422 Siming Nan Road, Xiamen, 361005 P. R. China;2. Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore, 117542 Singapore |
| |
| Abstract: | Silk fibroin (SF) has attracted great interest in bone tissue engineering due to its extraordinary characteristics in terms of mechanical properties, biocompatibility, and biodegradability. SF scaffolds are assembled by biocompatible polydopamine nanoparticles at mesoscopic scale, which endows the scaffolds with a near-infrared (NIR) light response for the treatment of bone tumors. The functionalized SF scaffold not only enhances the significant structure and performance of native SF scaffold for bone treatment and reconstruction, such as primary and mesoscopic structure, multi-level pores, and biodegradation, as well as biocompatibility but also have excellent photothermal effect leading a significant cytotoxicity to MG63 cancer cells after NIR laser irradiation. Moreover, the penetration of NIR light in tissue is improved using an optical fiber, which demonstrates the obtained scaffolds’ great potential in the application of photothermal therapy. |
| |
| Keywords: | photothermal therapy polydopamine scaffolds silk fibroin |
|
|
