| Affiliation: | 1. Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China
Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory for Nanomedicine, Guangdong Medical University, Dongguan, 523808 P. R. China;2. Shenzhen Key Laboratory Microbiology and Gene Engineering, Shenzhen University, Shenzhen, 518060 P. R. China;3. Guangdong Provincial Key Laboratory of Robotics and Intelligent System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055 P. R. China;4. Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory for Nanomedicine, Guangdong Medical University, Dongguan, 523808 P. R. China;5. Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China |
| Abstract: | Micro/nanorobots have the potential to be remotely propelled and manipulated in complex biological fluid and organ tissue. However, the combination of the sophisticated physiological barriers, remote-controlled navigation, real-time motion tracking, and diagnostic/therapeutic effects are tremendous challenges for application and translation. An unique sequential magneto-actuated and optics-triggered biomicrorobot (AI microrobot) for actively targeted cancer treatment is prepared. The AI microrobot consists of two components, magnetospirillum magneticum (AMB-1), providing the ability to autonomously swim toward the tumor site via internal hypoxia-driven effects and an external applied magnetic field, and indocyanine green nanoparticles, acting as a fluorescence imaging agent and photothermal therapy. The AI microrobots are tracked in vivo by fluorescence and magnetic resonance imaging. It is found that the AI microrobots can sequentially migrate to the hypoxic internal area of tumors and then effectively eradicate solid tumors through photothermal therapy under NIR laser irradiation. The sequential magneto-actuated and optics-triggered AI microrobots platform described here presents a bioinspired strategy toward remotely controlled propulsion, actively targeted cargo delivery, and satisfactory therapeutic performance in the circulatory system. |
