Impact of the inversion time on regional brain perfusion estimation with clinical arterial spin labeling protocols |
| |
Authors: | Sanvito Francesco Palesi Fulvia Rognone Elisa Barzaghi Leonardo Pasca Ludovica Germani Giancarlo De Giorgis Valentina Borgatti Renato Gandini Wheeler-Kingshott Claudia A M Pichiecchio Anna |
| |
Affiliation: | 1.Unit of Radiology, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Viale Camillo Golgi, 19, 27100, Pavia, Italy ;2.Department of Brain and Behavioral Sciences, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy ;3.Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy ;4.Advanced Imaging and Radiomics, Department of Neuroradiology, IRCCS Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy ;5.Department of Mathematics, University of Pavia, Via Adolfo Ferrata 5, 27100, Pavia, Italy ;6.Department of Child Neurology and Psychiatry, IRCCS Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy ;7.NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, Gower Street, WC1E 6BT, London, England, UK ; |
| |
Abstract: | Objective Evaluating the impact of the Inversion Time (TI) on regional perfusion estimation in a pediatric cohort using Arterial Spin Labeling (ASL). Materials and methodsPulsed ASL (PASL) was acquired at 3 T both at TI 1500 ms and 2020 ms from twelve MRI-negative patients (age range 9–17 years). A volume of interest (VOIs) and a voxel-wise approach were employed to evaluate subject-specific TI-dependent Cerebral Blood Flow (CBF) differences, and grey matter CBF Z-score differences. A visual evaluation was also performed. ResultsCBF was higher for TI 1500 ms in the proximal territories of the arteries (PTAs) (e.g. insular cortex and basal ganglia ?—? P?<?0.01 and P?<?0.05 from the VOI analysis, respectively), and for TI 2020 ms in the distal territories of the arteries (DTAs), including the watershed areas (e.g. posterior parietal and occipital cortex — P?<?0.001 and P?<?0.01 from the VOI analysis, respectively). Similar differences were also evident when analyzing patient-specific CBF Z-scores and at a visual inspection. ConclusionsTI influences ASL perfusion estimates with a region-dependent effect. The presence of intraluminal arterial signal in PTAs and the longer arterial transit time in the DTAs (including watershed areas) may account for the TI-dependent differences. Watershed areas exhibiting a lower perfusion signal at short TIs (~?1500 ms) should not be misinterpreted as focal hypoperfused areas. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|