Recent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering |
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Authors: | Xu Xue Yan Hu Yonghui Deng Jiacan Su |
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Affiliation: | 1. Institute of Translational Medicine, Shanghai University, Shanghai, 200444 China;2. Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, 200433 China;3. Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai, 200433 China |
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Abstract: | Bone related diseases have caused serious threats to human health owing to their complexity and specificity. Fortunately, owing to the unique 3D network structure with high aqueous content and functional properties, emerging hydrogels are regarded as one of the most promising candidates for bone tissue engineering, such as repairing cartilage injury, skull defect, and arthritis. Herein, various design strategies and synthesis methods (e.g., 3D-printing technology and nanoparticle composite strategy) are introduced to prepare implanted hydrogel scaffolds with tunable mechanical strength, favorable biocompatibility, and excellent bioactivity for applying in bone regeneration. Injectable hydrogels based on biocompatible materials (e.g., collagen, hyaluronic acid, chitosan, polyethylene glycol, etc.) possess many advantages in minimally invasive surgery, including adjustable physicochemical properties, filling irregular shapes of defect sites, and on-demand release drugs or growth factors in response to different stimuli (e.g., pH, temperature, redox, enzyme, light, magnetic, etc.). In addition, drug delivery systems based on micro/nanogels are discussed, and its numerous promising designs used in the application of bone diseases (e.g., rheumatoid arthritis, osteoarthritis, cartilage defect) are also briefed in this review. Particularly, several key factors of hydrogel scaffolds (e.g., mechanical property, pore size, and release behavior of active factors) that can induce bone tissue regeneration are also summarized in this review. It is anticipated that advanced approaches and innovative ideas of bioactive hydrogels will be exploited in the clinical field and increase the life quality of patients with the bone injury. |
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Keywords: | biocompatible materials bone tissue engineering drug delivery hydrogels |
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