| 新型二羟基手性磷酸催化剂的合成 |
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| 引用本文： | 姚元勇,BHADURY Pinaki-shankar,薛伟. 新型二羟基手性磷酸催化剂的合成[J]. 精细化工, 2013, 30(1): 41-44 |
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| 作者姓名： | 姚元勇 BHADURY Pinaki-shankar 薛伟 |
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| 作者单位： | 贵州大学精细化工研究开发中心,贵州大学精细化工研究开发中心,贵州大学精细化工研究开发中心 |
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| 基金项目： | 国家自然科学基金(No. 21062005) 和贵州大学人才科研基金 (No. 201122)资助 |
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| 摘 要： | 以1,1'-联二萘酚〔(R)-BINOL〕为原料,在n-BuLi的作用下对BINOL的3,3'位上进行修饰,获得(R)-3,3'-双(二苯基羟基甲基)-2,2'-二羟基-1,1'-联二萘(Ⅰc),并通过羟基选择性保护,磷酸化反应,将其转化为具有潜在能力的手性磷酸催化剂(Ⅱa),收率52%。
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| 关 键 词： | BrΦnsted酸 BINOL 手性磷酸 催化剂 |
| 收稿时间： | 2012-10-26 |
| 修稿时间： | 2012-12-10 |
Synthesis of newly chiral phosphoric acid catalyst carrying two hydroxyls |
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| YAO Yuan-yong,BHADURY Pinaki-shankar and XUE Wei. Synthesis of newly chiral phosphoric acid catalyst carrying two hydroxyls[J]. Fine Chemicals, 2013, 30(1): 41-44 |
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| Authors: | YAO Yuan-yong BHADURY Pinaki-shankar XUE Wei |
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| Affiliation: | Guizhou University,Guizhou University |
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| Abstract: | The intermediate Ⅰc of(R)-3,3′-bis(hydroxyldiphenylmethyl)-[1,1′-binaphthalene]-2,2′-diol was obtained by modification of(R)-BINOL at 3,3′ positions under the interaction of n-BuLi,and then was converted successfully into the potent axially dissymmetric binaphthyl phosphoric acid Ⅱa through selective hydroxyls protection,and phosphonation.The yield reached 52%. |
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| Keywords: | BrΦnsted acid BINOL chiral phosphoric acid catalyst |
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