| 依帕司他中间体α-甲基肉桂醛的合成 |
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| 引用本文： | 左华,赵宝祥,王大威.依帕司他中间体α-甲基肉桂醛的合成[J].精细化工中间体,2003,33(6):36-37. |
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| 作者姓名： | 左华 赵宝祥 王大威 |
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| 作者单位： | 山东大学化学与化工学院有机化学研究所,山东,济南,250100 |
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| 摘 要： | 研究了由苯甲醛、丁醛合成α 甲基肉桂醛的工艺,考察了催化剂用量、原料摩尔比、反应时间对合成α 甲基肉桂醛收率的影响。其优化条件是:以乙醇作溶剂,四丁基溴化铵为催化剂,n(苯甲醛)∶n(丙醛)∶n(催化剂)1 4∶1∶0 015,室温反应6h,收率达84 6%,且过量的苯甲醛能回收。
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| 关 键 词： | 相转移催化 苯甲醛 丙醛 α-甲基肉桂醛 合成 |
| 文章编号： | 1009-9212(2003)06-0036-02 |
| 修稿时间： | 2003年6月16日 |
The Synthesis of α-Methylcinnamaldehyde as Intermediate of Epalrestat |
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| ZUO Hua,etc.The Synthesis of α-Methylcinnamaldehyde as Intermediate of Epalrestat[J].Fine Chemical Intermediates,2003,33(6):36-37. |
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| Authors: | ZUO Hua etc |
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| Abstract: | The influence factors on the yield of α-methylcinnamaldehyde, such as kind of catalysts, dosage of catalyst, molar ratio of benzaldehyde to n propylaldehyde, and reaction time were investigated. The optimum preparation conditions are as follows∶n(benzaldehyde)∶n(n propylaldehyde)∶n(catalyst)=1.4∶1∶0.015, 6 h of reaction time with ethanol as solvent, tetrabutylammonium bromide as catalyst, and reacting at room temperature. The yield of α methylcinnamaldehyde reaches 84.6%, and surplus benzaldehyde could be used recyclely. |
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| Keywords: | phase transfer catalysis α-methylcinnamaldehyde synthesis |
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